Corollary Discharge Abnormalities in Patients with Schizophrenia

On Wednesday 27 July 2011, Dr Thomas Whitford, NHMRC (CJ Martin) Postdoctoral Research Fellow at the Melbourne Neuropsychiatry Centre Department of Psychiatry at The University of Melbourne, will speak on the subject of, 'Corollary Discharge Abnormalities in Patients with Schizophrenia: Evidence from Electroencephalography and Diffusion-Tensor Imaging'.
 
Schizophrenia patients have been found to exhibit abnormally high levels of electroencephalographic activity to self-generated sensations. These self-suppression abnormalities have been argued to underlie the tendency of schizophrenia patients to confuse self-generated and externally-generated actions (e.g., delusions of control). It has been suggested that these self-suppression abnormalities are ultimately caused by abnormalities in the neural signals, known as corollary discharges (CDs), that are involved in suppressing the sensory consequences of self-generated actions and thereby ‘tagging’ them as self-generated. The nature of these abnormalities is unknown. This talk will discuss the existing evidence for CD abnormalities in schizophrenia, and will present new evidence suggesting that schizophrenia patients may, in response to self-generated auditory stimulation, experience CDs that are abnormally delayed in their arrival at the auditory cortex, possibly because of structural damage to the white matter fasciculus linking the sites of CD generation and destination.  
 
DETAILS
 
Date: Wednesday 27 July 2011
Time: 12-1pm
Location: Level 7 Auditorium, QBI Building (#79), St.Lucia Campus
 
For a list of upcoming seminars at QBI, go to http://www.qbi.uq.edu.au/neuroscience-seminars
 

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