Professor Huji Xu

Contact Information

huji.xu@uq.edu.au
Building: QBI Building #79
Room: 
Tel: +61 7 334 66348

Mailing Address

Queensland Brain Institute
The University of Queensland
Brisbane, 4072
Queensland
Australia

Links

Lab Members

Lab Home Page

Short biography 

Research directions

Current collaborations

Selected publications

 

Short biography

Professor Huji Xu holds an appointment with the Queensland Brain Institute at The University of Queensland and the Second Military Medical University (SMMU) in Shanghai.

Research directions

Professor Huji Xu's work probes the neurogenetics of motor neuron disease (MND), schizophrenia, stroke and epilepsy.

Researchers in hislaboratory are engaging with a network of neurologists and psychiatrists at various hospitals and universities across China to study ethnically remote populations. It is anticipated that differences in ancestral genetic diversity will enable mapping of genes in certain populations that are not easily identified in other populations.

Current collaborations 

Selected publications

  • Xu H, Hodder AN, Yan H, Crewther PE, Anders RF, Good MF (2000) CD4+ T cells acting independently of antibody contribute to protective immunity to Plasmodium chabaudi infection after apical membrane antigen 1 immunization. Journal of Immunology 165: 389-396.
  • Xu H, Wipasa J, Yan H, Zeng M, Makobongo MO, Finkelman FD, Kelso A, Good MF (2002) The mechanism and significance of deletion of parasite-specific CD4+ T cells in malaria infection. Journal of Experimental Medicine 195: 881-892.
  • Makobongo MO, Riding G, Xu H, Hirunpetcharat C, Keough D, de Jersey J, Willadsen P, Good MF (2003) The purine salvage enzyme hypoxanthine guanine xanthine phosphoribosyl transferase is a major target antigen for cell-mediated immunity to malaria. Proceedings of the National Academy of Sciences of the USA 100: 2628-2633.
  • Good MF, Xu H, Wykes M, Engwerda CR (2005) Development and regulation of cell-mediated immune responses to the blood stages of malaria: implications for vaccine research. Annual Review of Immunology 23: 69-99.
  • Dai SM, Shan ZZ, Xu H, Nishioka K (2007) Cellular targets of interleukin-18 in rheumatoid arthritis. Annals of the Rheumatic Diseases 66: 1411-1418.
  • Fan K, Dai J, Wang H, Wei H, Cao Z, Hou S, Qian W, Li B, Zhao J, Xu H, Yang C, Guo Y. (2008) Treatment of collagen-induced arthritis with an anti-osteopontin monoclonal antibody through promotion of apoptosis of both murine and human activated T cells. Arthritis & Rheumatism 58: 2041-5202.
  • Davidson SI, Wu X, Liu Y, Wei M, Danoy PA, Thomas G, Cai Q, Sun L, Duncan E, Wang N, Yu Q, Xu A, Fu Y, Brown MA, Xu H (2009) Association of ERAP1, but not IL23R, with ankylosing spondylitis in a Han Chinese population. Arthritis & Rheumatism 60: 3263-3268.
  • Cheng F, Guo Z, Xu H, Yan D, Li Q (2009) Decreased plasma IL22 levels, but not increased IL17 and IL23 levels, correlate with disease activity in patients with systemic lupus erythematosus. Annals of the Rheumatic Diseases 68: 604-606.
  • Liu Y, Jiang L, Cai Q, Danoy P, Barnardo MC, Brown MA, Xu H. (2010) Predominant association of HLA-B*2704 with ankylosing spondylitis in Chinese Han patients. Tissue Antigens 75: 61-64.
  • Davidson SI, Liu Y, Danoy PA, Wu X, Thomas GP, Jiang L, Sun L, Wang N, Han J, Han H, Visscher PM, Brown MA, Xu H (2011) Association of STAT3 and TNFRSF1A with ankylosing spondylitis in Han Chinese. Annals of the Rheumatic Diseases 70: 289-292.
  • Zhao DB, Dai SM, Liu XP, Xu H (2011) Interstitial inflammation in visceral organs is a pathologic feature of adult-onset Still's disease. Rheumatology International 31: 923-927.
  • The Australo-Anglo-American Spondyloarthritis Consortium & the Wellcome Trust Case Control Consortium 2 (Xu H. Chinese principal investigator) (2011) Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. Nature Genetics 43: 761-767.
  • Danoy P, Wei M, Johanna H, Jiang L, He D, Sun L, Zeng X, Visscher PM, Brown MA, Xu H (2011) Association of variants in MMEL1 and CTLA4 with rheumatoid arthritis in the Han Chinese population. Annals of the Rheumatic Diseases (in press)

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