A small transparent roundworm with the remarkable ability to self-heal may hold the secret to treating nerve injuries in humans.
In a study published in the renowned scientific journal Nature, QBI scientists have discovered the molecular mechanisms that allow severed nerves in roundworms to fuse back together.
Project leader Associate Professor Massimo Hilliard said the findings provided hope for treating nerve injuries.
“This will now open new avenues to try to exploit this knowledge in other systems closer to human physiology, and hopefully move further towards solving nerve injuries,” Associate Professor Hilliard said.
“We’ll now try to understand if a similar process occurs in vertebrates and, if it doesn’t, how we can use what we have learned from worms to make it happen and then scale it up towards humans,” he said.
Associate Professor Hilliard said neurosurgery could be combined with molecular biology in the future to deliver clinical outcomes, and perhaps treat conditions such as spinal cord injury or vascular damage where healthy neurons were injured.
“Neurosurgery alone to fix nerve injuries by effectively trying to stitch together broken nerves has had limited success,” he said.
“But a combined approach using molecular biology might create an environment that is much more conducive for regeneration, and we may be able to deliver molecules that act as a glue to enable healing.”
Nerve injuries can take on many forms, from temporary to permanent, and can involve impaired function for abilities such as sensory or motor control.
Lead author of the research paper, Dr Brent Neumann, said the C. elegans roundworm was an ideal model for studying the nervous system.
“We study the roundworm species C. elegans because its transparency, simplistic structure, and known genetics allow us to easily understand the processes that occur inside its body,” Dr Neumann said.
“This meant we were able to progress rapidly, and go from a description of what happens, to understanding the very process of how it happens on a genetic and molecular level.”
QBI collaborated with the University of Colorado, Boulder, and the research was funded by the National Health and Medical Research Council, the Australian Research Council and the National Institutes of Health.