A/Professor Paul Lockhart received his PhD from the University of Melbourne in 2000. He was awarded a NHMRC CJ Martin Fellowship to study the genetics of neurodegenerative disorders, specifically Parkinson's disease, with Professor John Hardy and Professor Matthew Farrer at The Mayo Clinic, Florida. Paul returned to Australia in 2004 and joined the newly formed Bruce Lefroy Centre (BLC) at the Murdoch Childrens Research Institute.

In 2009 he became Co-Director of the Bruce Lefroy Centre and expanded his research activities to include gene identification utilising modern genomic technologies. He works in close collaboration with the Victorian Clinical Genetics Service to identify and characterise the genetic basis of rare Mendelian genetic disorders in families presenting to the clinic. Currently he is a NHMRC Career Development Fellow and leads a laboratory group that investigates the molecular basis of neurogenetic disorders.