Dr Victor Anggono completed his Bachelor of Science degree, majoring in pharmacology, at the University of New South Wales.
He then began his PhD in 2003 with Professor Phil Robinson at the Children’s Medical Research Institute, University of Sydney. There he studied the role of phosphorylation of the protein dynamin I in synaptic vesicle endocytosis – an important mechanism, whereby a nerve cell recaptures and reuses membranes that have fused with the plasma membrane to release neurotransmitters, allowing cells to signal to one another.
During his PhD, Dr Anggono discovered the protein syndapin was an essential partner to dynamin in regulating this process. His discoveries in this area resulted in a number of first-authored publications, including one in Nature Neuroscience.
In 2007, supported by an International Human Frontiers Science Program Long-Term Fellowship and an NHMRC CJ Martin Fellowship, Dr Anggono undertook postdoctoral work at The Johns Hopkins University in Baltimore under the mentorship of Professor Richard Huganir to study the trafficking of neurotransmitter receptors and its implication in synaptic plasticity, learning and memory.
In 2011, Dr Anggono was awarded an Australian Society for Biochemistry and Molecular Biology Boomerang Award, which provides an expatriate biochemist or molecular biologist with the opportunity to return to Australia to present his or her work at a prestigious conference and give seminars at universities and research institutes around the country. It was Dr Anggono’s presentation at QBI as part of this award that resulted in his recruitment to the Institute.
Dr Anggono officially joined QBI in March 2012 as a research fellow to begin establishing an independent research group in what is now the Clem Jones Centre for Ageing Dementia Research (CJCADR). He and his team are primarily interested in dissecting out the cellular signalling pathways that control the release of neurotransmitters from presynaptic neurons and the trafficking of neurotransmitter receptors on postsynaptic neurons.
Such research is important not only to improve our understanding of the fundamental biological process of synaptic transmission that controls synaptic plasticity, learning and memory, but it may also provide novel insights into the development of better ways to overcome synaptic dysfunctions that are responsible for the cognitive decline in dementia.