Associate Professor Darryl Eyles is the head of the Queensland Centre for Mental Health Research Developmental Neurobiology laboratory. Darryl’s research focuses exclusively on how known risk-factors for schizophrenia change the way the brain develops. His group have established the biological plausibility of various epidemiological risk factors for this disease. Much of the research focuses on the effects of developmental vitamin D, (DVD), deficiency on brain development. He also is interested in the effects Advanced Paternal Age and how this may relate to both autism and schizophrenia. Darryl has also established models of impaired dopaminergic development in the fly and zebra fish brains in order to investigate how the two major theories of schizophrenia namely the “Dopamine Hypothesis” and the “Neurodevelopmental Hypothesis“ of schizophrenia can be synthesised.
The group approach is to create models based on known epidemiologically-informed risk factors for serious mental illness and examine brain structure at a gross, cellular and molecular level. These risk factors continue to be informed by major collaborations with a psychiatrist based at QBI, Professor John McGrath. In collaboration with Associate Professor Tom Burne the group attempts to understand how early changes in brain development could affect some basic (locomotor) and complex (learning and memory) animal behaviours.
Awards include a 2002 Queensland Health Award and in 2003 a Forum for European-Australian Science and Technology Cooperation award.
- Professor John McGrath
- Associate Professor Tom Burne
- Associate Professor Bruno Van Swinderen
- Dr Ethan Scott
- Associate Professor M Belgrove
External to QBI
- Professor F Feron - Marseille, France
- Professor A Becker - Magdeburg, Germany
- Dr D Hougaard - Copenhagen, Denmark
- Dr Pamela von Hurst - New Zealand
- Associate Professor Rebecca J. Schmidt - UC Davis
- Professor Emma Whitelaw - QIMR
- Professor Dallas English, - University of Melbourne
- Professor Anne-Louise Ponsonby - Murdoch Childrens Research Institute
- Dr M Cairns - University of Newcastle
- Dr I van-der Mei - University of Tasmania/The University of Queensland
- McGrath, Eyles, Pedersen, Anderson, Ko, Burne, Norgaard-Pedersen, Hougaard, Mortensen. (2010) Neonatal vitamin D status and risk of schizophrenia: a population-based case-control study. Arch Gen Psychiatry. 67(9): 889-894.
- Kesby J, Cui X, O'Loan J, McGrath J, Burne T, Eyles D (2010) Developmental vitamin D deficiency alters dopamine-mediated behaviors and dopamine transporter function in adult female rats. Psychopharmacology (Berl). 208(1):159-68.
- Eyles DW, Feron F, Cui X, Kesby JP, Harms LH, Ko P, McGrath JJ, Burne TH (2009) Developmental vitamin D deficiency causes abnormal brain development. Psychoneuroendocrinology (2009) 34S, S247—S257.
- Kesby JP, Burne THJ, McGrath JJ, Eyles DW (2006) Developmental vitamin D deficiency alters MK 801-induced hyperlocomotion in the adult rat: an animal model of schizophrenia. Biol Psychiatry. 60:591-596.
- Eyles DW, Smith S, Kinobe R, Hewison M, McGrath JJ (2005) Distribution of the vitamin D receptor and 1α-hydroxylase in human brain. J Chem Neuroanat: 29(1) 21-30.
- Eyles D, Brown J; Mackay-Sim A, McGrath J, Feron F. (2003) Vitamin D3 and brain development. Neuroscience 118 (3) 641 – 653.