Bryan is a graduate in medicine from The University of Queensland and holds a BA (Hons) degree in philosophy from the University of Western Australia. A medical specialist in psychiatry, he is a clinician researcher, who is Conjoint Professor at the Queensland Brain Institute, University of Queensland, and Director of Genetics at the Queensland Centre for Mental Health Research. His primary research interest is the molecular genetics of schizophrenia, and holds a MD degree (The University of Queensland) in this field.
Since 1990, he has conducted studies, with national and international collaborators, to identify susceptibility genes for this disorder. He is the recipient of grants from the Australian NHMRC and the US NIMH.
The primary research goal is to identify and functionally characterise susceptibility genes for schizophrenia and related disorders. A special focus is on the study of large collaborative samples and ethnically homogeneous populations. Key methodologies used in the lab include genome-wide association studies, next-generation sequencing, transcriptome profiling of post-mortem brain samples, neurocognitive and neuroimaging phenotyping and induced pluripotent stem cells.
Current areas of interest include pharmacogenomics of clozapine treatment response, whole exome sequencing focused on de novo mutations, and the neuroimmunology of schizophrenia
- Dr Rangaswamy Thara - Schizophrenia Research Foundation (SCARF), Chennai, India
- Prof Matthew Brown - Diamantina Institute, The University of Queensland
- A/Prof Naomi Wray - Queensland Brain Institute, The University of Queensland
- Prof Peter Visscher - Queensland Brain Institute, The University of Queensland
- Prof David Reutens - Centre for Advanced Imaging, The University of Queensland
- Prof Lynn Jorde - University of Utah School of Medicine, Salt Lake City, Utah
- Psychiatric Genetics Consortium, Schizophrenia
- Molecular Genetics of Schizophrenia Consortium
- Australian Schizophrenia Research Bank
Queensland Centre for Mental Health Research Genetics Group
Gratten J, Visscher PM, Mowry BJ and Wray NR (2013) Interpreting the role of de novo protein-coding mutations in neuropsychiatric disease. Nat Genet 45:234-238.
Mowry BJ and Gratten J (2013) The emerging spectrum of allelic variation in schizophrenia: current evidence and strategies for the identification and functional characterization of common and rare variants. Mol Psychiatry 18:38-52.
Fanous AH, …, Mowry BJ, … Levinson DF (2012) Genome-wide association study of clinical dimensions of schizophrenia: polygenic effect on disorganized symptoms. Am J Psychiatry 169:1309-17.
Ragan C, Mowry BJ and Bauer DC (2012) Hybridization-based reconstruction of small non-coding RNA transcripts from deep sequencing data. Nucleic Acids Res 40:7633-43.
McLean D, John S, Barrett R, McGrath J, Loa P, Thara R and Mowry B (2012) Refining clinical phenotypes by contrasting ethnically different populations with schizophrenia from Australia, India and Sarawak. Psychiatry Res 196:194-200.
Levinson DF, …, Mowry BJ, … Holmans PA (2012) Genome-wide association study of multiplex schizophrenia pedigrees. Am J Psychiatry 169:963-73.
Simonson TS, Xing J, Barrett R, Jerah E, Loa P, Zhang Y, Watkins WS, Witherspoon DJ, Huff CD, Woodward S, Mowry B and Jorde LB (2011) Ancestry of the Iban is predominantly southeast asian: genetic evidence from autosomal, mitochondrial, and y chromosomes. PLoS One 6:e16338.
Ripke S, …, Mowry BJ, …Gejman PV (2011) Genome-wide association study identifies five new schizophrenia loci. Nat Genet 43:969-76.
Levinson DF, …, Mowry BJ, … Gejman PV (2011) Copy Number Variants in Schizophrenia: Confirmation of Five Previous Findings and New Evidence for 3q29 Microdeletions and VIPR2 Duplications. Am J Psychiatry 168:302-316.
Holliday EG, … Mowry BJ (2009) Strong Evidence for a Novel Schizophrenia Risk Locus on Chromosome 1p31.1 in Homogeneous Pedigrees From Tamil Nadu, India. Am J Psychiatry 166:206-215.