Professor Bryan Mowry - Psychiatric Genomics

 

Professor Bryan Mowry

 Contact Information

   b.mowry@uq.edu.au
  Building: QBI Building #79
  Room: 451
  Tel: +61 7 3346 6351

 Mailing Address

  Queensland Brain Institute
  The University of Queensland
  Brisbane, 4072 
  Queensland,
  Australia

 Links

 Lab Members

 Lab Home Page

Short biography

Research directions

Current collaborations

Selected publications

Short biography

Bryan is a graduate in medicine from the University of Queensland and holds a BA (Hons) degree in philosophy from the University of Western Australia. Both clinician and researcher, he is Director of Genetics at the Queensland Centre for Mental Health Research and Conjoint Professor of Psychiatry at the Queensland Brain Institute, University of Queensland. Bryan's primary research interest is the molecular genetics of schizophrenia, and holds a MD degree (University of Queensland) in this field. Since 1990, he has conducted studies, with national and international collaborators, to identify susceptibility genes for this disorder. He is the recipient of grants from the Australian NHMRC and the US NIMH.  


Research directions

TThe primary research goal is to identify genes for schizophrenia and related disorders using molecular and statistical genetic approaches. A special focus is on the study of large collaborative samples and ethnically homogeneous populations. The group also has an interest in identifying alternate clinical phenotypes for increasing the power of genetic analyses. Our lab is increasingly using second-generation sequencing to comprehensively ascertain genetic variation including those underlying statistical associations with disease, as well as to perform genomewide expression analyses on post-mortem brain samples. We are also seeking to incorporate induced pluripotent stem cell technology as a means of developing cellular models for schizophrenia.

Bryan is also the Chair of the users committee for QBI’s newly formed Centre for Brain Genomics.

Current collaborations

  • Prof Matthew Brown, Diamantina Institute of Cancer, Immunology and Metabolic Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane
  • Prof Pablo Gejman, Center for Psychiatric Genetics, ENH Research Institute, Evanston-Northwestern Univ. Research Park, Chicago
  • Dr Elizabeth Holliday, University of Newcastle, Newcastle, Australia
  • Prof Lynn Jorde, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, USA
  • Prof Douglas Levinson, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto
  • Dr Stuart MacGregor, Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane
  • Dr Dale Nyholt, Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane
  • Prof Christos Pantelis, The Melbourne Neuropsychiatry Centre (MNC), Department of Psychiatry, University of Melbourne, Melbourne
  • Prof David Reutens, Centre for Advanced Imaging, University of Queensland, Brisbane
  • Dr Rangaswamy Thara, Director, Schizophrenia Research Foundation (SCARF), Chennai, India
  • A/Prof Bruno van Swinderen, Queensland Brain Institute, University of Queensland, Brisbane
  • Prof Peter Visscher, Queensland Statistical Genetics, Queensland Institute of Medical Research, Brisbane

Queensland Centre for Mental Health Research Genetics Group

http://www.qcsr.uq.edu.au/genetics.htm

Selected publications

Simonson TS, Xing JC, Barrett R, Jerah E, Loa P, Zhang YH, Watkins WS, Witherspoon DJ, Huff CD, Woodward S, Mowry B, Jorde LB. Ancestry of the Iban Is Predominantly Southeast Asian: Genetic Evidence from Autosomal, Mitochondrial, and Y Chromosomes. PLoS One. 2011; 6(1).

Levinson DF, Duan JB, Oh S, Wang K, Sanders AR, Shi JX, Zhang N, Mowry BJ, Olincy A, Amin F, Cloninger CR, Silverman JM, Buccola NG, Byerley WF, Black DW, Kendler KS, Freedman R, Dudbridge F, Pe'er I, Hakonarson H, Bergen SE, Fanous AH, Holmans PA, Gejman PV. Copy Number Variants in Schizophrenia: Confirmation of Five Previous Findings and New Evidence for 3q29 Microdeletions and VIPR2 Duplications. American Journal of Psychiatry. 2011; 168(3): 302-16.

Fornito A, Zalesky A, Bassett DS, Meunier D, Ellison-Wright I, Yucel M, Wood SJ, Shaw K, O'Connor J, Nertney D, Mowry BJ, Pantelis C, Bullmore ET. Genetic Influences on Cost-Efficient Organization of Human Cortical Functional Networks. Journal of Neuroscience. 2011; 31(9): 3261-70.

Xing JC, Watkins WS, Witherspoon DJ, Zhang YH, Guthery SL, Thara R, Mowry BJ, Bulayeva K, Weiss RB, Jorde LB. Fine-scaled human genetic structure revealed by SNP microarrays. Genome Research. 2009; 19(5): 815-25.

Shi JX, Levinson DF, Duan JB, Sanders AR, Zheng YL, Pe'er I, Dudbridge F, Holmans PA, Whittemore AS, Mowry BJ, Olincy A, Amin F, Cloninger CR, Silverman JM, Buccola NG, Byerley WF, Black DW, Crowe RR, Oksenberg JR, Mirel DB, Kendler KS, Freedman R, Gejman PV. Common variants on chromosome 6p22.1 are associated with schizophrenia. Nature. 2009; 460(7256): 753-7.

Holliday EG, Nyholt DR, Tirupati S, John S, Ramachandran P, Ramamurti M, Ramadoss AJ, Jeyagurunathan A, Kottiswaran S, Smith HJ, Filippich C, Nertney DA, Nancarrow DJ, Hayward NK, Watkins WS, Jorde LB, Thara R, Mowry BJ. Strong Evidence for a Novel Schizophrenia Risk Locus on Chromosome 1p31.1 in Homogeneous Pedigrees From Tamil Nadu, India. American Journal of Psychiatry. 2009; 166(2): 206-15.

Holliday EG, McLean DE, Nyholt DR, Mowry BJ. Susceptibility Locus on Chromosome 1q23-25 for a Schizophrenia Subtype Resembling Deficit Schizophrenia Identified by Latent Class Analysis. Archives of General Psychiatry. 2009; 66(10): 1058-67.

 


On this site

Go to top