Associate Professor Naomi Wray - Statistical and psychiatric genetics

Associate Professor Naomi Wray

 Contact Information

  naomi.wray@uq.edu.au
  Building: #79
  Room: 432
  Tel: +61 7 334 66374

 Mailing Address

  Queensland Brain Institute
  The University of Queensland
  Brisbane, 4072
  Queensland,
  Australia

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Short biography

Research directions

Current collaborations

Selected Publications

Short Biography

Naomi Wray is an ARC Future Fellow and an NHMRC Honorary Senior Research Fellow. Her early training was in quantitative genetics with application in livestock, which provides a strong theoretical foundation for her research today. She holds a BSc in Animal Science from the University of Edinburgh (1984), an MS in Animal Breeding and Statistics from Cornell (1986) and a PhD in Quantitative Genetics from the University of Edinburgh (1989). Her career path from livestock genetics through epidemiology of childhood leukaemia to psychiatric genetics has been underpinned at each stage by a strong interest in underlying theory and practical applications. During the period 16 year period 1993-2009 she took a 5-year career break from research and otherwise worked part-time, working a total of < 7 years Full Time Equivalent. She moved to Australia in 2005 to join the Queensland Institute of Medical Research where she established and led the Psychiatric Genetics Laboratory. She joined QBI in 2011 to establish the Statistical and Psychiatric Genetics Laboratory.

Research directions

My broad interest is to understand the genetic contribution to individual differences between people. My research programme focuses on methodology in statistical and quantitative genetics (particularly associated with prediction of genetic risk) and application of new methods to genetically informative data sets of psychiatric disorders. My portfolio of current and recent grants reflects this mix of theory and application in psychiatric genetics. 

Current collaborations

Selected Publications 

Wray NR, Goddard ME, Visscher PM (2008) Prediction of individual genetic risk of complex disease. Current Opinion in Genes and Development 18:257-63. 

Purcell SM, Wray NR, Stone JL, Visscher PM, O’Donovan MC, Sullivan PF, Sklar P. International Schizophrenia Consortium (2009) Common polygenic variation plays an important role in schizophrenia. Nature460: 748-752

Evans DM, Visscher PM, Wray NR (2009). Harnessing the Information Contained Within Genome-wide Association Studies to Improve Individual Prediction of Complex Disease Risk. Human Molecular Genetics 18: 3525-3531

Wray NR, Visscher PM (2010) Narrowing the boundaries of the genetic architecture of schizophrenia. Schizophrenia Bulletin 36: 14-23.

Wray NR, Yang J, Goddard ME, Visscher PM (2010) The genetic interpretation of area under the ROC curve in individual risk prediction. PLoS Genetics e1000864

Wray NR, Purcell SM, Visscher PM (2011): Synthetic Associations Created by Rare Variants Do Not Explain Most GWAS Results. PLoS biology 9(1):e1000579

Lee SH, Wray NR, Goddard ME, Visscher PM (2011): Estimating Missing Heritability for Disease from Genome-wide Association Studies. American Journal of Human Genetics 88:294-305.

Wray NR, Pergadia ML, Blackwood DH, Penninx BW, Gordon SD, Nyholt DR, Ripke S, Macintyre DJ, McGhee KA, MacLean AW, Smit JH, Hottenga JJ, Willemsen G, Middeldorp CM, de Geus EJ, Lewis CM, McGuffin P, Hickie IB, van den Oord EJ, Liu JZ, Macgregor S, McEvoy BP, Byrne EM, Medland SE, Statham DJ, Henders AK, Heath AC, Montgomery GW, Martin NG, Boomsma DI, Madden PA, Sullivan PF (2012): Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned. Molecular Psychiatry 17: 36-48

Wray NR, Lee SH, Kendler KS (2012) Impact of diagnostic misclassification on estimation of genetic correlations using genome-wide genotypes. European Journal of Human Genetics (published online).

Lee S.H ,DeCandia T.R, Ripke S, … Wray NR (2012) Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs. Nature Genetics (accepted).

Visscher PM, Goddard ME, Derks EM, Wray NR (2011): Evidence-based psychiatric genetics, AKA the false dichotomy between common and rare variant hypotheses. Molecular Psychiatry epub 14 Jun 2011

 

 


    Group Members Based at Queensland Institute of Medical Research
      Natalie Mills
Child and Adolescent Psychiatrist, PhD student
(natalie.mills@qimr.edu.au		      

 

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