Professor Geoffrey Faullkner
 

Contact Information

geoffrey.faulkner@mater.uq.edu.au
Building: 
Room: 
Tel: +61 7 334 37587

Mailing Address

Mater Hospital
Raymond Terrace
South Brisbane, 4101
Queensland
Australia

Links

 

Short biography

Research directions

Selected publications

 

Short biography

 

Professor Geoff Faulkner is a computational and molecular biologist with research interests in transposable elements, genomics and neuroscience. Prof Faulkner completed undergraduate (2003), Honours (2004) and PhD (2009) degrees at the University of Queensland and established his laboratory at the University of Edinburgh in 2009. He relocated to the Mater Research Institute – University of Queensland (MRI–UQ) in 2012 and took up a joint appointment with the Queensland Brain Institute in 2016. 

Research directions

Our core research seeks to understand the role of retrotransposons, a type of “mobile DNA”, in causing genetic mosaicism in early mammalian embryogenesis, and in neurons. This variation may be a fundamental aspect of healthy brain function, and appears to change in neurological diseases, including Rett syndrome, schizophrenia and Alzheimer's disease. 

Selected publications 

Klawitter, S., Fuchs, N.V., Upton, K.R., Muñoz-Lopez, M., Shukla, R., Wang, J., Garcia-Canadas, M., Lopez-Ruiz, C., Gerhardt, D.J., Sebe, A., Grabundzija, I., Merkert, S., Gerdes, P., Pulgarin, J.A., Bock, A., Held, U., Witthuhn, A., Haase, A., Sarkadi, B., Löwer, J., Wolvetang, E.J., Martin, U., Ivics, Z., Izsvák, Z., Garcia-Perez, J.L*, Faulkner, G.J.* and Schumann, G.G.*, Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells. Nature Communications 7 (2016).

Upton, K.R., Gerhardt, D.J., Jesuadian, J.S., Richardson, S.R., Sanchez-Luque, F.J., Bodea, G.O., Salvador-Palomeque, C., van der Knaap, M.S., Brennan, P.M., Vanderver, A., Faulkner, G.J.*, Ubiquitous L1 mosaicism in hippocampal neurons. Cell 161, 228-239 (2015).

Richardson, S.R., Morell, S., Faulkner, G.J.*, L1 retrotransposons and somatic mosaicism in the brain. Annual Review of Genetics 48, 1-27 (2014).

Shukla, R., Upton, K.R., Muñoz-Lopez, M., Gerhardt, D.J., Fisher, M.E., Nguyen, T., Brennan P.M., Baillie, J.K., Collino, A., Ghisletti, S., Sinha, S., Iannelli, F., Radaelli, E., Dos Santos, A., Rapoud, D., Guettier, C., Samuel, D., Natoli, G., Carninci, P., Ciccarelli, F.D., Garcia-Perez, J.L., Faivre, J., Faulkner, G.J.* Endogenous retrotransposition activates oncogenic pathways in hepatocellular carcinoma. Cell 153, 101-111 (2013)

Baillie, J.K., Barnett, M.W., Upton, K.R., Gerhardt, D.J., Richmond, T., de Sapio, F., Brennan, P., Rizzu, P., Smith, S., Fell, M., Talbot, R.T., Gustincich, S., Freeman, T.C., Mattick., J.S., Hume, D.A., Heutink, P., Carninci, P., Jeddeloh, J.A., Faulkner, G.J.* Somatic retrotransposition alters the genetic landscape of the human brain. Nature 479, 534-537 (2011)

Faulkner, G.J., Kimura, Y., Daub, C.O., Wani, S., Plessy, C., Irvine, K.M., Schroder, K., Cloonan, N., Steptoe, A.L., Lassmann, T., Waki, K., Hornig, N., Arakawa, T., Takahashi, H., Kawai, J., Forrest, A.R.R., Suzuki, H., Hayashizaki, Y., Hume, D.A., Orlando, V., Grimmond, S.M., Carninci, P. The regulated retrotransposon transcriptome of mammalian cells. Nature Genetics 41, 563-71 (2009)